In the present work, fast disintegrating tablets of Telmisartan were prepared using novel co-processed superdisintegrants consisting of Croscarmellose sodium (CCS) and Crospovidone (CP) in different ratios (1:1, 1:2, 1:3, 1:4 & 1:1, 2:1, 3:1, 4:1). The developed superdisintegrants were evaluated for angle of repose, carr’s index and the type of flow. The angle of repose of the developed excipients was found to be <30°C, Carr’s index in the range of 12-21 %and the type of flow was good for all. Fast disintegrating tablets of Telmisartan were prepared using above co-processed superdisintegrants and evaluated for pre-compression and post-compression parameters. Based on the disintegration time (15 secs) , wetting time (8 secs), water absorption ratio (approx 86 %) and In-vitro dissolution time (within 2 mins), batch T8 was found to be the most promising batch. Stability (40°C/75%RH) and drug- excipients interaction (FT-IR & DSC) were also studied and no interaction between drug and excipients were revealed. Amongst all eight designed formulation, the formulation T8 containing 5% of co-processed superdisintegrants (4:1 i.e., 4 parts of CCS and 1 part of CP) emerged as the overall best formulation as compared to other ratios.
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